Exo Skin Cells Regeneration

Active powder of Exosomes (naturally formed extracellular vesicles) isolated from different untreated Fruits and vegetables (Grape, Orange, Pomegranate, Mandarin (Tangerine) and Papaya with synergistic effects. The Active powder is rich in: Superoxide Dismutase, Glutathione, Ascorbic Acid, Catalase. It is very stable and easily dispersible in water.

Origin
Grape, Orange, Pomegranate, Mandarin, and Papaya from Southern Italy Organic agriculture.

INCI Name
Vitis Vinifera Fruit Extract, Punica Granatum Fruit Extract, Citrus Reticulata Fruit Extract, Citrus Sinensis Fruit Extract, Carica Papaya Fruit Extract, Maltodextrin.

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Description

Benefits

Within the pool of exosomes, the boasted activities derive from the sum of the activities of the individual plant:

  • Contains resveratrol, a non flavonoid phenol found in grape skin and seeds. It has anti-inflammatory, antibacterial, antifungal, diuretic, antioxidant effects
  • Contains high levels of Vitamin A and C, folic acid, anthocyanins and calcium, Anti-aging and antiinflammatory effect
  • Contains Vitamin C and E, ellagic, tannins and polyphenols, Anti-aging effect
  • Improves skin tone, radiance and elasticity
  • Contains Lycopene, Vitamin A, papain and chymopapain.

(In vitro tests on Exo Elixir Regeneration)

Mitochondrial membrane potential Increasing
Wound healing is a highly metabolically demanding process, and mitochondria play a significant role in the wound healing cycle. Mitochondria are organelles that exist in large numbers within eukaryotic cells, Mitochondria are well known as being the cellular hubs for the generation and storage of energy in the form of adenosine triphosphate (ATP). It is very important to maintain mitochondria in good activity and productivity. The parameter that regulates the activity of the mitochondria is the mitochondrial membrane potential, and a high value indicates good activity.

In our test Oxidative stress was induced in Fibroblasts and subsequently they are treated with Exo Elixir Regeneration. After we verified the mitochondrial membrane potential compared to untreated cells. The mitochondrial membrane potential of treated cells is 487% higher than untreated ones.

In conclusion
Exo Elixir Regeneration restores mitochondrial membrane potential of stressed cells, so promotes fast wound healing.

+487% Mitochondrial Membrane Potential
Mitochondrial membrane potential increased by 487% compared to untreated cells, indicating rapid wound healing.

+100% Wound Healing repair
The test was performed on fibroblasts. After treatment with Skin Cells Regeneration, the wound closed 100% after 24 hours. While control fibroblasts had 70% wound closure.

+25% Sirtuin 1 Increase
Increased expression of Sirtuin 1 by 25% in treated cells, promoting skin regenerative activity.

Another important parameter to keep in mind in wound healing is the senescence condition of the fibroblasts. In fact the repair capacity is directly proportional to their vitality.
Sirtuin 1 is a protein that maintains fibroblasts in an optimal energy level and promotes their regeneration.

In our test
Oxidative stress was induced in Fibroblasts and subsequently they are treated with Exo Elixir Regeneration. After we verified the expression of Sirtuin 1 compared to untreated cells. Only in the treated cells we verify an increased expression of Sirtuin 1 (+25%).

In conclusion
Exo Elixir Regeneration helps and speed the skin regenerative activity.

  • Recommended use level: 1%
  • Easy to formulate.
  • Light coloured odourless powder
  • Totally water dispersible
  • Glycol / Glycerine / Ethanol compatibility
  • Stable at a wide range of pH
  • For emulsions: should be added once temperatures reach < 40°C, after the cooldown phase is complete, avoid homogenising after product adding.
  • For water-based systems: should be added at temperatures < 40°C.

  • Post aesthetic treatments Cosmetics
  • Skin Revitalising Cosmetics
  • Cica repair Creams

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